"Characterisation of a human monoclonal antibody targeting a conserved epitope at the base of the HA head of influenza A(H3N2) virus"
Yamayoshi S, Hamabata T, Inoue Y, Kiso M, Okuda M, Akasaka H, Shihoya W, Imamura T, Matsuzawa Y, Jubishi D, Iwatsuki-Horimoto K, Wilson PC, Nureki O, Kawaoka Y,
EBioMedicine.,
131
106450
(2026).
"Cryo-EM structure of the bicarbonate receptor GPR30"
Kaneda S, Jo-Watanabe A, Akasaka H, Oshima HS, Yokomizo T, Shihoya W, Nureki O,
Elife.,
13
RP99874
(2026).
"Targeted mutagenesis and base editing using engineered Brevibacillus laterosporus Cas9 with expanded target scope in rice"
Negishi K, Nishimasu H, Nureki O, Toki S, Endo M,
Plant Biotechnol (Tokyo).,
43(2)
151-160
(2026).
"Structure-guided development of a potent human B0AT1 inhibitor effective in a mouse model of phenylketonuria"
Imazu T, Akashi T, Hiraizumi M, Inui Y, Sasaki W, Takahashi T, Todoroki H, Kumanomidou T, Yamada K, Fujikawa N, Hisano H, Asada H, Kusakizako T, Nishizawa T, Iwata S, Nureki O, Miyaguchi I,
Commun Biol.,
(2026).
"Molecular mechanisms of naturally encoded signaling bias at the complement anaphylatoxin receptors"
Tiwari D, Sawada K, Dalal A, Mishra S, Li XX, Dent JC, Kim K, Yadav MK, Roy N, Ganguly M, Banerjee N, Stepniewski TM, Ahn D, Yamaguchi K, Oshima HS, Hashimoto K, Fung JN, Lerskiatiphanich T, Cui CS, Lee JD, Selent J, Inoue A, Clark RJ, Chung KY, Banerjee R, Sano FK, Woodruff TM, Nureki O, Shukla AK,
Mol Cell.,
86(13)
2586-2604
(2026).
"Structural insights into YheS-mediated release of SecM-arrested ribosome"
Iso K, Ikeda T, Yamasaki K, Ando Y, Sano FK, Furuta T, Taguchi H, Nureki O, Chadani Y, Itoh Y,
Nat Commun.,
17(1)
4963
(2026).
"Structure of ergosteryl-aspartate synthase reveals how an entrapped tRNA is used like a prosthetic swinging arm in the synthesis of aminoacylated sterols"
Murayama H, Yakobov N, Mahmoudi N, Legrosdidier S, Fournier N, Zuttion S, Matsumoto K, Nishimura M, Ji J, Senger B, Huck L, Gamper HB, Kise Y, Kleiner RE, Frechin M, Hou YM, Becker HD, Itoh Y, Fischer F, Nureki O,
Nat Commun.,
17(1)
4455
(2026).
"Structural insights into the ligand and G protein recognition by P2Y13R"
Oshima HS, Akasaka H, Sano FK, Nureki O,
Biochem Biophys Res Commun.,
827
153976
(2026).
"Structural basis and physiological significance of non-canonical Gs coupling to the melatonin MT1 receptor"
Oishi A, Okamoto HH, Ikegami K, McHugh R, Masri B, Kusakizako T, Kobayashi K, Takaki A, Karamitri A, Cecon E, Dam J, Nagase M, Tikhonova IG, Nureki O, Jockers R,
Nat Commun.,
17(1)
6706
(2026).
"Virological characteristics of SARS-CoV-2-related coronaviruses dynamically circulating in Southeast Asia"
Wacharapluesadee S, Saikruang W, Lytras S, Matsumoto K, Uriu K, Hinay A Jr, Guo Z, Rattanatumhi K, Supataragul A, Ninwattana S, Thippamom N, Srisuk T, Maneeorn P, Noradechanon K, Duengkae P, Sirichan N, Kosugi Y, Fujita S, Yo MS, Matsunaga R, Hu B, Du L, Wang L, Tsuda M, Oda Y, Nasser H, Kimura KT, Akasaka H, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Yamamoto Y, Nagamoto T, Asakura T, Shihoya W, Hashiguchi T, Ikeda T, Tanaka S, Chu H, Tsumoto K, Nureki O; Genotype to Phenotype Japan (G2P-Japan) Consortium; Genotype to Phenotype Asia (G2P-Asia) Consortium; Plianchaisuk A, Putcharoen O, Sato K,
Cell,
189(13)
4075-4093.e25
(2026).
"Engineering a compact high-fidelity Staphylococcus aureus Cas9 variant with broader targeting range and mechanistic insights into its activation"
Omura SN, Nakagawa R, Kajimoto S, Okazaki S, Ishiguro S, Mori H, Onishi K, Kashiwakura Y, Hiramoto T, Horinaka K, Tanaka M, Hirano H, Jividen K, Yamashita K, Tsai SQ, Yachie N, Ohmori T, Nishimasu H, Nureki O,
Nature commun,
17(1)
3584
(2026).
"Structural insights into inhibition mechanism of the helicase-primase complex from human herpesvirus 1"
Sato K, Ishida H, Miyagishi T, Kobayashi S, Kise Y, Hamada K, Okada C, Oguni A, Nureki O, Kono H, Fukuzawa K, Sengoku T,
Cell Chem Biol,
S2451-9456(26)00076-0
(2026).
"Structural basis for DNA processing and membrane translocation by ComEC in natural transformation"
Hirano H, Tsuji N, Chiba S, Nureki O,
Science,
392(6795)
311-316
(2026).
"HUH-tagged Cas9 as a platform for efficient ssODN-mediated knock-in via embryo and adult injection in insects"
Shirai Y, Kao JA, Kumar T, Matsuda N, Nakagawa R, Nureki O, Extavour CG, Daimon T,
Commun Biol,
9(1)
514
(2026).
"Molecular mechanism of MDA5 nucleation and filament formation by LGP2"
Kurihara N, Isayama Y, Zhang J, Yamashita T, Awaji K, Ito Y, Yoshizaki A, Kouwaki T, Oshiumi H, Nishimasu H, Shibata M, Nureki O, Kato K,
Mol Cell,
86(4)
707-721
(2026).
"Efficient and accurate prime editing system in plants"
Nishizawa-Yokoi A, Iida K, Mori A, Takemura M, Shuto Y, Nakagawa R, Nureki O, Toki S,
New Phytol,
249(5)
2163-2172
(2026).
"Photoaffinity Labeling Strategy Reveals Tetraspanin CD9 as a Transient Target of Anticancer Yaku'amide B"
Fu J, Kamiya K, Kitamura K, Kawahara R, Shihoya W, Nureki O, Hosoya S, Nakagawa R, Mashima T, Itoh H, Inoue M, Sakurai K,
J Am Chem Soc,
148(3)
2985-2994
(2026).
"Structure and evolution of the sequence-specific anti-silencing factor VANC21 and its target DNA"
Tanaka Y, Osakabe A, Shihoya W, Hirano H, Itoh Y, Kakutani T, Nureki O,
Genes Genet Syst,
101
(2026).
"Engineered coagulation factor VIII with enhanced secretion and coagulation potential for hemophilia A gene therapy"
Kashiwakura Y, Nakajima Y, Horinaka K, Lopes TJS, Furuta Y, Yamaguchi Y, Baatartsogt N, Hayakawa M, Katakai Y, Uchiyama S, Nureki O, Nogami K, Ohmori T,
Blood,
147(4)
402-415
(2026).
"Therapeutic base editing to generate a gain-of-function F9 variant for hemophilia B"
Baatartsogt N, Kashiwakura Y, Hiramoto T, Ito R, Sato R, Nagao Y, Naruoka H, Takata H, Hayakawa M, Batjargal K, Togashi T, Hoshino A, Shimizu T, Sato Y, Ishida T, Nureki O, Ohmori T,
Blood,
147(7)
458-470
(2026).
![[XXX]](/image/tw.png)
![[RSS]](/image/Feed-icon.png){kind=icon}