"SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine."
Mise-Omata, Setsuko, Ando, Makoto, Srirat, Tanakorn, Nakagawara, Kensuke, Hayakawa, Taeko, Iizuka-Koga, Mana, Nishimasu, Hiroshi, Nureki, Osamu, Ito, Minako, Yoshimura, Akihiko,
Cell Rep,
(2023).
"Structural Insights into Endothelin Receptor Signaling."
Shihoya, Wataru, Sano, Fumiya K, Nureki, Osamu,
J Biochem,
(2023).
"Mechanistic and evolutionary insights into a type V-M CRISPR-Cas effector enzyme."
Omura, Satoshi N, Nakagawa, Ryoya, Sudfeld, Christian, Villegas Warren, Ricardo, Wu, Wen Y, Hirano, Hisato, Laffeber, Charlie, Kusakizako, Tsukasa, Kise, Yoshiaki, Lebbink, Joyce H G, Itoh, Yuzuru, van der Oost, John, Nureki, Osamu,
Nat Struct Mol Biol,
(2023).
"Class B1 GPCR activation by an intracellular agonist."
Kobayashi, Kazuhiro, Kawakami, Kouki, Kusakizako, Tsukasa, Tomita, Atsuhiro, Nishimura, Michihiro, Sawada, Kazuhiro, Okamoto, Hiroyuki H, Hiratsuka, Suzune, Nakamura, Gaku, Kuwabara, Riku, Noda, Hiroshi, Muramatsu, Hiroyasu, Shimizu, Masaru, Taguchi, Tomohiko, Inoue, Asuka, Murata, Takeshi, Nureki, Osamu,
Nature,
(2023).
"Twisting and Protonation of Retinal Chromophore Regulate Channel Gating of Channelrhodopsin C1C2."
Shibata, Keisei, Oda, Kazumasa, Nishizawa, Tomohiro, Hazama, Yuji, Ono, Ryohei, Takaramoto, Shunki, Bagherzadeh, Reza, Yawo, Hiromu, Nureki, Osamu, Inoue, Keiichi, Akiyama, Hidefumi,
J Am Chem Soc,
(2023).
"Cryo-EM structure of the endothelin-1-ET(B)-G(i) complex."
Sano, Fumiya K, Akasaka, Hiroaki, Shihoya, Wataru, Nureki, Osamu,
Elife,
(2023).
"PAM-flexible Cas9-mediated base editing of a hemophilia B mutation in induced pluripotent stem cells."
Hiramoto, Takafumi, Kashiwakura, Yuji, Hayakawa, Morisada, Baatartsogt, Nemekhbayar, Kamoshita, Nobuhiko, Abe, Tomoyuki, Inaba, Hiroshi, Nishimasu, Hiroshi, Uosaki, Hideki, Hanazono, Yutaka, Nureki, Osamu, Ohmori, Tsukasa,
Commun Med (Lond),
(2023).
"Cryo-EM structure of the transposon-associated TnpB enzyme."
Nakagawa, Ryoya, Hirano, Hisato, Omura, Satoshi N, Nety, Suchita, Kannan, Soumya, Altae-Tran, Han, Yao, Xiao, Sakaguchi, Yuriko, Ohira, Takayuki, Wu, Wen Y, Nakayama, Hiroshi, Shuto, Yutaro, Tanaka, Tatsuki, Sano, Fumiya K, Kusakizako, Tsukasa, Kise, Yoshiaki, Itoh, Yuzuru, Dohmae, Naoshi, van der Oost, John, Suzuki, Tsutomu, Zhang, Feng, Nureki, Osamu,
Nature,
(2023).
"Genome editing in rice mediated by miniature size Cas nuclease SpCas12f."
Sukegawa, Satoru, Nureki, Osamu, Toki, Seiichi, Saika, Hiroaki,
Front Genome Ed,
(2023).
"Phototrophy by antenna-containing rhodopsin pumps in aquatic environments."
Chazan, Ariel, Das, Ishita, Fujiwara, Takayoshi, Murakoshi, Shunya, Rozenberg, Andrey, Molina-Marquez, Ana, Sano, Fumiya K, Tanaka, Tatsuki, Gomez-Villegas, Patricia, Larom, Shirley, Pushkarev, Alina, Malakar, Partha, Hasegawa, Masumi, Tsukamoto, Yuya, Ishizuka, Tomohiro, Konno, Masae, Nagata, Takashi, Mizuno, Yosuke, Katayama, Kota, Abe-Yoshizumi, Rei, Ruhman, Sanford, Inoue, Keiichi, Kandori, Hideki, Leon, Rosa, Shihoya, Wataru, Yoshizawa, Susumu, Sheves, Mordechai, Nureki, Osamu, Beja, Oded,
Nature,
(2023).
"Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility."
Futamata, Haon, Fukuda, Masahiro, Umeda, Rie, Yamashita, Keitaro, Tomita, Atsuhiro, Takahashi, Satoe, Shikakura, Takafumi, Hayashi, Shigehiko, Kusakizako, Tsukasa, Nishizawa, Tomohiro, Homma, Kazuaki, Nureki, Osamu,
Nat Commun,
(2022).
"Structure of the active G(i)-coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist."
Akasaka, Hiroaki, Tanaka, Tatsuki, Sano, Fumiya K, Matsuzaki, Yuma, Shihoya, Wataru, Nureki, Osamu,
Nat Commun,
(2022).
"Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP."
Imaizumi, Yuki, Takanuki, Kazunori, Miyake, Takuya, Takemoto, Mizuki, Hirata, Kunio, Hirose, Mika, Oi, Rika, Kobayashi, Tatsuya, Miyoshi, Kenichi, Aruga, Rie, Yokoyama, Tatsuhiko, Katagiri, Shizuka, Matsuura, Hiroaki, Iwasaki, Kenji, Kato, Takayuki, Kaneko, Mika K, Kato, Yukinari, Tajiri, Michiko, Akashi, Satoko, Nureki, Osamu, Hizukuri, Yohei, Akiyama, Yoshinori, Nogi, Terukazu,
Sci Adv,
(2022).
"The long beta2,3-sheets encoded by redundant sequences play an integral role in the channel function of P2X7 receptors."
Ma, Xue-Fei, Wang, Ting-Ting, Wang, Wen-Hui, Guan, Li, Guo, Chang-Run, Li, Xing-Hua, Lei, Yun-Tao, Fan, Ying-Zhe, Yang, Xiao-Na, Hattori, Motoyuki, Nureki, Osamu, Zhu, Michael X, Yu, Ye, Tian, Yun, Wang, Jin,
J Biol Chem,
(2022).
"Structure of the type V-C CRISPR-Cas effector enzyme."
Kurihara, Nina, Nakagawa, Ryoya, Hirano, Hisato, Okazaki, Sae, Tomita, Atsuhiro, Kobayashi, Kan, Kusakizako, Tsukasa, Nishizawa, Tomohiro, Yamashita, Keitaro, Scott, David A, Nishimasu, Hiroshi, Nureki, Osamu,
Mol Cell,
(2022).
"Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility."
Futamata H, Fukuda M, Umeda R, Yamashita K, Tomita A, Takahashi S, Shikakura T, Hayashi S, Kusakizako T, Nishizawa T, Homma K, Nureki O,
Nat Commun,
13
6208
(2022).
"Structure of the active Gi-coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist."
Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O,
Nat Commun,
13
5417
(2022).
"Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP."
Imaizumi Y, Takanuki K, Miyake T, Takemoto M, Hirata K, Hirose M, Oi R, Kobayashi T, Miyoshi K, Aruga R, Yokoyama T, Katagiri S, Matsuura H, Iwasaki K, Kato T, Kaneko MK, Kato Y, Tajiri M, Akashi S, Nureki O, Hizukuri Y, Akiyama Y, Nogi T,
Sci Adv,
8
eabp9011
(2022).
"Structure and engineering of the minimal type VI CRISPR-Cas13bt3."
Nakagawa R, Kannan S, Altae-Tran H, Takeda SN, Tomita A, Hirano H, Kusakizako T, Nishizawa T, Yamashita K, Zhang F, Nishimasu H, Nureki O,
Mol Cell,
(2022).
"Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2."
Kato T, Kusakizako T, Jin C, Zhou X, Ohgaki R, Quan L, Xu M, Okuda S, Kobayashi K, Yamashita K, Nishizawa T, Kanai Y, Nureki O,
Nat Commun,
13
4714
(2022).
"Endogenous ligand recognition and structural transition of a human PTH receptor."
Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O,
Mol Cell,
(2022).
"Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex."
Yamaguchi S, Naganuma M, Nishizawa T, Kusakizako T, Tomari Y, Nishimasu H, Nureki O,
Nature,
(2022).
"Recent Advances in the Structural Biology of the Volume-Regulated Anion Channel LRRC8."
Kasuya G, Nureki O,
Front Pharmacol,
13
896532
(2022).
"Lipidic cubic phase serial femtosecond crystallography structure of a photosynthetic reaction centre."
Bath P, Banacore A, Borjesson P, Bosman R, Wickstrand C, Safari C, Dods R, Ghosh S, Dahl P, Ortolani G, Bjorg Ulfarsdottir T, Hammarin G, Garcia Bonete MJ, Vallejos A, Ostojic L, Edlund P, Linse JB, Andersson R, Nango E, Owada S, Tanaka R, Tono K, Joti Y, Nureki O, Luo F, James D, Nass K, Johnson PJM, Knopp G, Ozerov D, Cirelli C, Milne C, Iwata S, Branden G, Neutze R,
Acta Crystallogr D Struct Biol,
78
698-708
(2022).
"Automated amplification-free digital RNA detection platform for rapid and sensitive SARS-CoV-2 diagnosis."
Shinoda H, Iida T, Makino A, Yoshimura M, Ishikawa J, Ando J, Murai K, Sugiyama K, Muramoto Y, Nakano M, Kiga K, Cui L, Nureki O, Takeuchi H, Noda T, Nishimasu H, Watanabe R,
Commun Biol,
5
473
(2022).
"The long beta2,3-sheets encoded by redundant sequences play an integral role in the channel function of P2X7 receptors."
Ma XF, Wang TT, Wang WH, Guan L, Guo CR, Li XH, Lei YT, Fan YZ, Yang XN, Hattori M, Nureki O, Zhu MX, Yu Y, Tian Y, Wang J,
J Biol Chem,
102002
(2022).
"Cryo-EM structures of thylakoid-located voltage-dependent chloride channel VCCN1."
Hagino T, Kato T, Kasuya G, Kobayashi K, Kusakizako T, Hamamoto S, Sobajima T, Fujiwara Y, Yamashita K, Kawasaki H, Maturana AD, Nishizawa T, Nureki O,
Nat Commun,
13
2505
(2022).
"Cryo-EM structures of the beta3 adrenergic receptor bound to solabegron and isoproterenol."
Nureki I, Kobayashi K, Tanaka T, Demura K, Inoue A, Shihoya W, Nureki O,
Biochem Biophys Res Commun,
611
158-164
(2022).
"Molecular mechanisms of building blocks of life towards medicinal applications."
Nureki O,
Keio J Med,
71
32
(2022).
"Structure of the type V-C CRISPR-Cas effector enzyme."
Kurihara N, Nakagawa R, Hirano H, Okazaki S, Tomita A, Kobayashi K, Kusakizako T, Nishizawa T, Yamashita K, Scott DA, Nishimasu H, Nureki O,
Mol Cell,
(2022).
"Engineered Campylobacter jejuni Cas9 variant with enhanced activity and broader targeting range."
Nakagawa R, Ishiguro S, Okazaki S, Mori H, Tanaka M, Aburatani H, Yachie N, Nishimasu H, Nureki O,
Commun Biol,
5
211
(2022).
"Cell-Free Synthesis of Human Endothelin Receptors and Its Application to Ribosome Display."
Nakai H, Isshiki K, Hattori M, Maehira H, Yamaguchi T, Masuda K, Shimizu Y, Watanabe T, Hohsaka T, Shihoya W, Nureki O, Kato Y, Watanabe H, Matsuura T,
Anal Chem,
(2022).
"Conformational alterations in unidirectional ion transport of a light-driven chloride pump revealed using X-ray free electron lasers."
Hosaka T, Nomura T, Kubo M, Nakane T, Fangjia L, Sekine SI, Ito T, Murayama K, Ihara K, Ehara H, Kashiwagi K, Katsura K, Akasaka R, Hisano T, Tanaka T, Tanaka R, Arima T, Yamashita A, Sugahara M, Naitow H, Matsuura Y, Yoshizawa S, Tono K, Owada S, Nureki O, Kimura-Someya T, Iwata S, Nango E, Shirouzu M,
Proc Natl Acad Sci U S A,
119
(2022).
"Lateral access mechanism of LPA receptor probed by molecular dynamics simulation."
Suenaga R, Takemoto M, Inoue A, Ishitani R, Nureki O,
PLoS One,
17
e0263296
(2022).
"Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine."
Kishi KE, Kim YS, Fukuda M, Inoue M, Kusakizako T, Wang PY, Ramakrishnan C, Byrne EFX, Thadhani E, Paggi JM, Matsui TE, Yamashita K, Nagata T, Konno M, Quirin S, Lo M, Benster T, Uemura T, Liu K, Shibata M, Nomura N, Iwata S, Nureki O, Dror RO, Inoue K, Deisseroth K, Kato HE,
Cell,
(2022).
"Pharmacophore-guided Virtual Screening to Identify New beta3-Adrenergic Receptor Agonists."
Ujiantari NSO, Ham S, Nagiri C, Shihoya W, Nureki O, Hutchinson D, Schuster D,
Mol Inform,
(2021).
"Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus."
Iriki H, Takahashi H, Wada N, Nomura H, Mukai M, Kamata A, Ito H, Yamagami J, Matsui T, Kurebayashi Y, Mise-Omata S, Nishimasu H, Nureki O, Yoshimura A, Hori S, Amagai M,
Proc Natl Acad Sci U S A,
118
(2021).
"Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2."
Sato K, Kumar A, Hamada K, Okada C, Oguni A, Machiyama A, Sakuraba S, Nishizawa T, Nureki O, Kono H, Ogata K, Sengoku T,
Nat Commun,
12
6605
(2021).
"Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2."
Tomita A, Daiho T, Kusakizako T, Yamashita K, Ogasawara S, Murata T, Nishizawa T, Nureki O,
Mol Cell,
(2021).
"Structural basis of gating modulation of Kv4 channel complexes."
Kise Y, Kasuya G, Okamoto HH, Yamanouchi D, Kobayashi K, Kusakizako T, Nishizawa T, Nakajo K, Nureki O,
Nature,
(2021).
"Cryo-EM structure of the human MT1-Gi signaling complex."
Okamoto HH, Miyauchi H, Inoue A, Raimondi F, Tsujimoto H, Kusakizako T, Shihoya W, Yamashita K, Suno R, Nomura N, Kobayashi T, Iwata S, Nishizawa T, Nureki O,
Nat Struct Mol Biol,
(2021).
"Cryo-EM structure of the beta3-adrenergic receptor reveals the molecular basis of subtype selectivity."
Nagiri C, Kobayashi K, Tomita A, Kato M, Kobayashi K, Yamashita K, Nishizawa T, Inoue A, Shihoya W, Nureki O,
Mol Cell,
(2021).
"Precise CAG repeat contraction in a Huntington's Disease mouse model is enabled by gene editing with SpCas9-NG."
Oura S, Noda T, Morimura N, Hitoshi S, Nishimasu H, Nagai Y, Nureki O, Ikawa M,
Commun Biol,
4
771
(2021).
"The structure of MgtE in the absence of magnesium provides new insights into channel gating."
Jin F, Sun M, Fujii T, Yamada Y, Wang J, Maturana AD, Wada M, Su S, Ma J, Takeda H, Kusakizako T, Tomita A, Nakada-Nakura Y, Liu K, Uemura T, Nomura Y, Nomura N, Ito K, Nureki O, Namba K, Iwata S, Yu Y, Hattori M,
PLoS Biol,
19
e3001231
(2021).
"Amplification-free RNA detection with CRISPR-Cas13."
Shinoda H, Taguchi Y, Nakagawa R, Makino A, Okazaki S, Nakano M, Muramoto Y, Takahashi C, Takahashi I, Ando J, Noda T, Nureki O, Nishimasu H, Watanabe R,
Commun Biol,
4
476
(2021).
"Conserved binding site in the N-lobe of prokaryotic MATE transporters suggests a role for Na(+) in ion-coupled drug efflux."
Castellano S, Claxton DP, Ficici E, Kusakizako T, Stix R, Zhou W, Nureki O, Mchaourab HS, Faraldo-Gomez JD,
J Biol Chem,
296
100262
(2021).
"Crystal structure of schizorhodopsin reveals mechanism of inward proton pumping."
Higuchi A, Shihoya W, Konno M, Ikuta T, Kandori H, Inoue K, Nureki O,
Proc Natl Acad Sci U S A,
118
(2021).
"Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin."
Oda K, Nomura T, Nakane T, Yamashita K, Inoue K, Ito S, Vierock J, Hirata K, Maturana AD, Katayama K, Ikuta T, Ishigami I, Izume T, Umeda R, Eguma R, Oishi S, Kasuya G, Kato T, Kusakizako T, Shihoya W, Shimada H, Takatsuji T, Takemoto M, Taniguchi R, Tomita A, Nakamura R, Fukuda M, Miyauchi H, Lee Y, Nango E, Tanaka R, Tanaka T, Sugahara M, Kimura T, Shimamura T, Fujiwara T, Yamanaka Y, Owada S, Joti Y, Tono K, Ishitani R, Hayashi S, Kandori H, Hegemann P, Iwata S, Kubo M, Nishizawa T, Nureki O,
Elife,
10
(2021).
"Cex1 is a component of the COPI intracellular trafficking machinery."
Enkler L, Rinaldi B, de Craene JO, Hammann P, Nureki O, Senger B, Friant S, Becker HD,
Biol Open,
10
(2021).
"Alternating Heterochiral Supramolecular Copolymerization."
Ueda M, Aoki T, Akiyama T, Nakamuro T, Yamashita K, Yanagisawa H, Nureki O, Kikkawa M, Nakamura E, Aida T, Itoh Y,
J Am Chem Soc,
(2021).
"Non-viral ex vivo genome-editing in mouse bona fide hematopoietic stem cells with CRISPR/Cas9."
Byambaa S, Uosaki H, Ohmori T, Hara H, Endo H, Nureki O, Hanazono Y,
Mol Ther Methods Clin Dev,
20
451-462
(2021).
"N(6)-methyladenosine (m(6)A) is an endogenous A3 adenosine receptor ligand."
Ogawa A, Nagiri C, Shihoya W, Inoue A, Kawakami K, Hiratsuka S, Aoki J, Ito Y, Suzuki T, Suzuki T, Inoue T, Nureki O, Tanihara H, Tomizawa K, Wei FY,
Mol Cell,
(2021).
"Conserved binding site in the N-lobe of prokaryotic MATE transporters suggests a role for Na(+) in ion-coupled drug efflux."
Castellano S, Claxton DP, Ficici E, Kusakizako T, Stix R, Zhou W, Nureki O, Mchaourab HS, Faraldo-Gomez JD,
J Biol Chem,
(2021).
"Mitochondrial sorting and assembly machinery operates by beta-barrel switching."
Takeda H, Tsutsumi A, Nishizawa T, Lindau C, Busto JV, Wenz LS, Ellenrieder L, Imai K, Straub SP, Mossmann W, Qiu J, Yamamori Y, Tomii K, Suzuki J, Murata T, Ogasawara S, Nureki O, Becker T, Pfanner N, Wiedemann N, Kikkawa M, Endo T,
Nature,
4
(2021).
![[XXX]](/image/tw.png)
![[RSS]](/image/Feed-icon.png){kind=icon}