"Structure of the miniature type V-F CRISPR-Cas effector enzyme."
Takeda SN, Nakagawa R, Okazaki S, Hirano H, Kobayashi K, Kusakizako T, Nishizawa T, Yamashita K, Nishimasu H, Nureki O,
Mol Cell,
(2020).
"B/N-Doped p-Arylenevinylene Chromophores: Synthesis, Properties, and Microcrystal Electron Crystallographic Study"
Lu H, Nakamuro T, Yamashita K, Yanagisawa H, Nureki O, Kikkawa M ,Gao H, Tian J, Shang R, Nakamura E,
J. Am. Chem. Soc.,
(2020).
"Consensus mutagenesis approach improves the thermal stability of system xc (-) transporter, xCT, and enables cryo-EM analyses."
Oda K, Lee Y, Wiriyasermkul P, Tanaka Y, Takemoto M, Yamashita K, Nagamori S, Nishizawa T, Nureki O,
Protein Sci,
(2020).
"Structural basis for unique color tuning mechanism in heliorhodopsin."
Tanaka T, Singh M, Shihoya W, Yamashita K, Kandori H, Nureki O,
Biochem Biophys Res Commun,
(2020).
"Spiro-Conjugated Carbon/Heteroatom-Bridged p-Phenylenevinylenes: Synthesis, Properties, and Microcrystal Electron Crystallographic Analysis of Racemic Solid Solutions."
Hamada H, Nakamuro T, Yamashita K, Yanagisawa H, Nureki O, Kikkawa M ,Harano K, Shang R, Nakamura E,
BCSJ,
(2020).
"Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies."
Demura K, Kusakizako T, Shihoya W, Nishizawa T, Hiraizumi M, Nomura K, Shimada H, Yamashita K, Nishizawa T, Taruno A, Nureki O,
Sci Adv,
(2020).
"The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism."
Shimada H, Kusakizako T, Dung Nguyen TH, Nishizawa T, Hino T, Tominaga M, Nureki O,
Nat Struct Mol Biol,
(2020).
"Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation."
Nakamura R, Numata T, Kasuya G, Yokoyama T, Nishizawa T, Kusakizako T, Kato T, Hagino T, Dohmae N, Inoue M, Watanabe K, Ichijo H, Kikkawa M, Shirouzu M, Jentsch TJ, Ishitani R, Okada Y, Nureki O,
Commun Biol,
3
240
(2020).
"Structural insights into tetraspanin CD9 function."
Umeda R, Satouh Y, Takemoto M, Nakada-Nakura Y, Liu K, Yokoyama T, Shirouzu M, Iwata S, Nomura N, Sato K, Ikawa M, Nishizawa T, Nureki O,
Nat Commun,
11
1606
(2020).
"Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein."
Kobayashi K, Shihoya W, Nishizawa T, Marie F, Kadji N, Aoki J, Inoue A, Nureki O,
Nat Struct Mol Biol,
27
274-280
(2020).
"Crystal structure of Drosophila Piwi."
Yamaguchi S, Oe A, Nishida KM, Yamashita K, Kajiya A, Hirano S, Matsumoto N, Dohmae N, Ishitani R, Saito K, Siomi H, Nishimasu H, Siomi MC, Nureki O,
Nat Commun,
11
858
(2020).
"Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b."
Izume T, Miyauchi H, Shihoya W, Nureki O,
Biochem Biophys Res Commun,
(2020).
"Structural biology of the multidrug and toxic compound extrusion superfamily transporters."
Kusakizako T, Miyauchi H, Ishitani R, Nureki O,
Biochim Biophys Acta Biomembr,
183154
(2019).
"Crystal structure of heliorhodopsin. "
Shihoya W, Inoue K, Singh M, Konno M, Hososhima S, Yamashita K, Ikeda K, Higuchi A, Izume T, Okazaki S, Hashimoto M, Mizutori R, Tomida S, Yamauchi Y, Abe-Yoshizumi R, Katayama K, Tsunoda SP, Shibata M, Furutani Y, Pushkarev A, Beja O, Uchihashi T, Kandori H, Nureki O ,
Nature ,
(2019 ).
"Cryo-EM structures capture the transport cycle of the P4-ATPase flippase."
Hiraizumi M, Yamashita K, Nishizawa T, Nureki O,
Science,
(2019).
"Crystal structure of human endothelin ETB receptor in complex with peptide inverse agonist IRL2500."
Nagiri C, Shihoya W, Inoue A, Kadji FMN, Aoki J, Nureki O,
Communications Biology,
(2019).
"Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc."
Lee Y, Wiriyasermkul P, Jin C, Quan L, Ohgaki R, Okuda S, Kusakizako T, Nishizawa T, Oda K, Ishitani R, Yokoyama T, Nakane T, Shirouzu M, Endou H, Nagamori S, Kanai Y, Nureki O,
Nat Struct Mol Biol,
26
510-517
(2019).
"Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9."
Hirano S, Abudayyeh OO, Gootenberg JS, Horii T, Ishitani R, Hatada I, Zhang F, Nishimasu H, Nureki O,
Nat Commun,
10
1968
(2019).
"Structural basis for oligomerization of the prokaryotic peptide transporter PepTSo2."
Nagamura R, Fukuda M, Kawamoto A, Matoba K, Dohmae N, Ishitani R, Takagi J, Nureki O,
Acta Crystallogr F Struct Biol Commun,
75
348-358
(2019).
"Crystallization of the human tetraspanin protein CD9."
Umeda R, Nishizawa T, Nureki O,
Acta Crystallogr F Struct Biol Commun,
75
254-259
(2019).
"Crystal structure of plant vacuolar iron transporter VIT1."
Kato T, Kumazaki K, Wada M, Taniguchi R, Nakane T, Yamashita K, Hirata K, Ishitani R, Ito K, Nishizawa T, Nureki O,
Nat Plants,
(2019).
"Crystal structure of the Agrobacterium tumefaciens type VI effector-immunity complex."
Fukuhara S, Nakane T, Yamashita K, Ishii R, Ishitani R, Nureki O,
Acta Crystallogr F Struct Biol Commun,
74
810-816
(2018).
"Cap-specific terminal N (6)-methylation of RNA by an RNA polymerase II-associated methyltransferase. "
Akichika S, Hirano S, Shichino Y, Suzuki T, Nishimasu H, Ishitani R, Sugita A, Hirose Y, Iwasaki S, Nureki O, Suzuki T ,
Science ,
(2019 ).
"Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation."
Shihoya W, Izume T, Inoue A, Yamashita K, Kadji FMN, Hirata K, Aoki J, Nishizawa T, Nureki O,
Nat Commun,
9
4711
(2018).
"Structural Basis of H(+)-Dependent Conformational Change in a Bacterial MATE Transporter."
Kusakizako T, Claxton DP, Tanaka Y, Maturana AD, Kuroda T, Ishitani R, Mchaourab HS, Nureki O,
Structure,
(2018).
"Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1."
Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Kasuya G, Ishitani R, Tokunaga F, Nureki O,
Nat Commun,
9
4424
(2018).
"Crystal structure of the red light-activated channelrhodopsin Chrimson."
Oda K, Vierock J, Oishi S, Rodriguez-Rozada S, Taniguchi R, Yamashita K, Wiegert JS, Nishizawa T, Hegemann P, Nureki O,
Nat Commun,
9
3949
(2018).
"Free Energy Landscape for the Entire Transport Cycle of Triose-Phosphate/Phosphate Translocator."
Takemoto M, Lee Y, Ishitani R, Nureki O,
Structure,
26
1284-1296.e4
(2018).
"Engineered CRISPR-Cas9 nuclease with expanded targeting space."
Nishimasu H, Shi X, Ishiguro S, Gao L, Hirano S, Okazaki S, Noda T, Abudayyeh OO, Gootenberg JS, Mori H, Oura S, Holmes B, Tanaka M, Seki M, Hirano H, Aburatani H, Ishitani R, Ikawa M, Yachie N, Zhang F, Nureki O,
Science,
(2018).
"Cryo-EM structures of the human volume-regulated anion channel LRRC8."
Kasuya G, Nakane T, Yokoyama T, Jia Y, Inoue M, Watanabe K, Nakamura R, Nishizawa T, Kusakizako T, Tsutsumi A, Yanagisawa H, Dohmae N, Hattori M, Ichijo H, Yan Z, Kikkawa M, Shirouzu M, Ishitani R, Nureki O,
Nat Struct Mol Biol,
(2018).
"Crystallographic Analysis of MATE-Type Multidrug Exporter with Its Inhibitors."
Kusakizako T, Tanaka Y, Hipolito CJ, Suga H, Nureki O,
Methods Mol Biol,
1700
37-57
(2018).
"Structural basis for xenobiotic extrusion by eukaryotic MATE transporter."
Miyauchi H, Moriyama S, Kusakizako T, Kumazaki K, Nakane T, Yamashita K, Hirata K, Dohmae N, Nishizawa T, Ito K, Miyaji T, Moriyama Y, Ishitani R, Nureki O,
Nat Commun,
8
1633
(2017).
"Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy."
Shibata M, Nishimasu H, Kodera N, Hirano S, Ando T, Uchihashi T, Nureki O,
Nat Commun,
8
1430
(2017).
"Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel."
Kasuya G, Yamaura T, Ma XB, Nakamura R, Takemoto M, Nagumo H, Tanaka E, Dohmae N, Nakane T, Yu Y, Ishitani R, Matsuzaki O, Hattori M, Nureki O,
Nat Commun,
8
876
(2017).
"Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity."
Lee Y, Nishizawa T, Takemoto M, Kumazaki K, Yamashita K, Hirata K, Minoda A, Nagatoishi S, Tsumoto K, Ishitani R, Nureki O,
Nat Plants,
(2017).
"X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog."
Shihoya W, Nishizawa T, Yamashita K, Inoue A, Hirata K, Kadji FMN, Okuta A, Tani K, Aoki J, Fujiyoshi Y, Doi T, Nureki O,
Nat Struct Mol Biol,
(2017).
"Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6."
Taniguchi R, Inoue A, Sayama M, Uwamizu A, Yamashita K, Hirata K, Yoshida M, Tanaka Y, Kato HE, Nakada-Nakura Y, Otani Y, Nishizawa T, Doi T, Ohwada T, Ishitani R, Aoki J, Nureki O,
Nature,
(2017).
"Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1."
Yamano T, Zetsche B, Ishitani R, Zhang F, Nishimasu H, Nureki O,
Mol Cell,
(2017).
"ATP-dependent modulation of MgtE in Mg2+ homeostasis."
Tomita A, Zhang M, Jin F, Zhuang W, Takeda H, Maruyama T, Osawa M, Hashimoto KI, Kawasaki H, Ito K, Dohmae N, Ishitani R, Shimada I, Yan Z, Hattori M, Nureki O,
Nat Commun,
8
148
(2017).
"Structural Basis for the Altered PAM Recognition by Engineered CRISPR-Cpf1."
Nishimasu H, Yamano T, Gao L, Zhang F, Ishitani R, Nureki O,
Mol Cell,
(2017).
"Applications of the CRISPR-Cas9 system in kidney research."
Higashijima Y, Hirano S, Nangaku M, Nureki O,
Kidney Int,
(2017).
"Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA."
Kato K, Omura H, Ishitani R, Nureki O,
Annu Rev Biochem,
(2017).
"Hydroxyethyl cellulose matrix applied to serial crystallography"
Sugahara M, Nakane T, Masuda T, Suzuki M, Inoue S, Song C, Tanaka R, Nakatsu T, Mizohata E, Yumoto F, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Nureki O, Numata K, Nango E & Iwata S ,
Sci. Rep.,
7
703
(2017).
"Atomic resolution structure of serine protease proteinase K at ambient temperature"
Masuda T, Suzuki M, Inoue S, Song C, Nakane T, Nango E, Tanaka R, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Mikami B, Nureki O, Numata K, Iwata S & Sugahara M,
Sci. Rep.,
7
45604
(2017).
"Structural insights into the nucleotide base specificity of P2X receptors."
Kasuya G, Fujiwara Y, Tsukamoto H, Morinaga S, Ryu S, Touhara K, Ishitani R, Furutani Y, Hattori M, Nureki O,
Sci Rep,
7
45208
(2017).
"Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems."
Yamada M, Watanabe Y, Gootenberg JS, Hirano H, Ran FA, Nakane T, Ishitani R, Zhang F, Nishimasu H, Nureki O,
Mol Cell,
65
1109-1121.e3
(2017).
"A three-dimensional movie of structural changes in bacteriorhodopsin"
Nango E, Royant A, Kubo M, Nakane T, Wickstrand C, Kimura T, Tanaka T, Tono K, Song C, Tanaka R, Arima T, Yamashita A, Kobayashi J, Hosaka T, Mizohata E, Nogly P, Sugahara M, Nam D, Nomura T, Shimamura T, Im D, Fujiwara T, Yamanaka Y, Jeon B, Nishizawa T, Oda K, Fukuda M, Andersson R, Båth P, Dods R, Davidsson J, Matsuoka S, Kawatake S, Murata M, Nureki O, Owada S, Kameshima T, Hatsui T, Joti Y, Schertler G, Yabashi M, Bondar AN, Standfuss J, Neutze R, Iwata S,
Science,
(2016).
"Structures and mechanisms of CRISPR RNA-guided effector nucleases."
Nishimasu H, Nureki O,
Curr Opin Struct Biol,
(2016).
"Crystal structures of the TRIC trimeric intracellular cation channel orthologues."
Kasuya G, Hiraizumi M, Maturana AD, Kumazaki K, Fujiwara Y, Liu K, Nakada-Nakura Y, Iwata S, Tsukada K, Komori T, Uemura S, Goto Y, Nakane T, Takemoto M, Kato HE, Yamashita K, Wada M, Ito K, Ishitani R, Hattori M, Nureki O,
Cell Res,
(2016).
"The light-driven sodium ion pump: A new player in rhodopsin research."
Kato HE, Inoue K, Kandori H, Nureki O,
Bioessays,
(2016).
"Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent."
Nakane T, Hanashima S, Suzuki M, Saiki H, Hayashi T, Kakinouchi K, Sugiyama S, Kawatake S, Matsuoka S, Matsumori N, Nango E, Kobayashi J, Shimamura T, Kimura K, Mori C, Kunishima N, Sugahara M, Takakyu Y, Inoue S, Masuda T, Hosaka T, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Inoue T, Nureki O, Iwata S, Murata M, Mizohata E,
Proc Natl Acad Sci U S A,
(2016).
"Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide."
Omura H, Oikawa D, Nakane T, Kato M, Ishii R, Ishitani R, Tokunaga F, Nureki O,
Sci Rep,
(2016).
"Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA."
Matsumoto N, Nishimasu H, Sakakibara K, Nishida KM, Hirano T, Ishitani R, Siomi H, Siomi MC, Nureki O,
Cell,
(2016).
"Activation mechanism of endothelin ETB receptor by endothelin-1."
Shihoya W, Nishizawa T, Okuta A, Tani K, Dohmae N, Fujiyoshi Y, Nureki O, Doi T,
Nature,
(2016).
"Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization"
Kato K, Satouh Y, Nishimasu H, Kurabayashi A, Morita J, Fujihara Y, O,
Nat Commun,
7
12198
(2016).
"Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide."
Morita J, Kato K, Nakane T, Kondo Y, Fukuda H, Nishimasu H, Ishitani ,
Nat Commun,
7
12383
(2016).
"LCP crystallization and X-ray diffraction analysis of VcmN, a MATE transporter from Vibrio cholerae."
Kusakizako T, Tanaka Y, Hipolito CJ, Kuroda T, Ishitani R, Suga H, Nureki O,
Acta Crystallogr F Struct Biol Commun,
(2016).
"Structural basis for amino acid export by DMT superfamily transporter YddG."
Tsuchiya H, Doki S, Takemoto M, Ikuta T, Higuchi T, Fukui K, Usuda Y, Tabuchi E, Nagatoishi S, Tsumoto K, Nishizawa T, Ito K, Dohmae N, Ishitani R, Nureki O,
Nature,
534
417-20
(2016).
"Data processing pipeline for serial femtosecond crystallography at SACLA."
Nakane T; Joti Y; Tono K; Yabashi M; Nango E; Iwata S; Ishitani R; Nureki O,
J Appl Crystallogr,
(2016).
"Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA."
Yamano T, Nishimasu H, Zetsche B, Hirano H, Slaymaker IM, Li Y, Fedorova I, Nakane T, Makarova KS, Koonin EV, Ishitani R, Zhang F, Nureki O,
Cell,
(2016).
"Conductance of P2X4 purinergic receptor is determined by conformational equilibrium in the transmembrane region."
Minato Y, Suzuki S, Hara T, Kofuku Y, Kasuya G, Fujiwara Y, Igarashi S, Suzuki E, Nureki O, Hattori M, Ueda T, Shimada I,
Proc Natl Acad Sci U S A,
(2016).
"Structural basis for specific inhibition of Autotaxin by a DNA aptamer."
Kato K, Ikeda H, Miyakawa S, Futakawa S, Nonaka Y, Fujiwara M, Okudaira S, Kano K, Aoki J, Morita J, Ishitani R, Nishimasu H, Nakamura Y, Nureki O,
Nat Struct Mol Biol,
(2016).
"Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas9."
Hirano S, Nishimasu H, Ishitani R, Nureki O,
Mol Cell,
(2016).
"Recent developments in CrystFEL"
Thomas A. White, Valerio Mariani, Wolfgang Brehm, Oleksandr Yefanov, Anton Barty, Kenneth R. Beyerlein, Fedor Chervinskii, Lorenzo Galli, Cornelius Gati, Takanori Nakane, Alexandra Tolstikova, Keitaro Yamashita, Chun Hong Yoon, Kay Diederichs and Henry N. Chapman,
Acta Cryst. D.,
49
680-689
(2016).
"Redox-coupled proton transfer mechanism in nitrite reductase revealed by femtosecond crystallography"
Fukuda Y, Tse KM, Nakane T, Nakatsu T, Suzuki M, Sugahara M, Inoue S, Masuda T, Yumoto F, Matsugaki N, Nango E, Tono K, Joti Y, Kameshima T, Song C, Hatsui T, Yabashi M, Nureki O, Murphy MEP, Inoue T, Iwata S, Mizohata E,
Proc Natl Acad Sci U S A,
(2016).
"Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase"
Morita J, Kano K, Kato K, Takita H, Sakagami H, Yamamoto Y, Mihara E, Ueda H, Sato T, Tokuyama H, Arai H, Asou H, Takagi J, Ishitani R, Nishimasu H, Nureki O, Aoki J,
Sci Rep.,
6
20995
(2016).
"Structure and Engineering of Francisella novicida Cas9"
Hirano H, Gootenberg JS, Horii T, Abudayyeh OO, Kimura M, Hsu PD, Nakane T, Ishitani R, Hatada I, Zhang F, Nishimasu H, Nureki O,
Cell.,
164
950-961
(2016).
"Redox-coupled structural changes in nitrite reductase revealed by serial femtosecond and microfocus crystallography"
Fukuda Y, Tse KM, Suzuki M, Diederichs K, Hirata K, Nakane T, Sugahara M, Nango E, Tono K, Joti Y, Kameshima T, Song C, Hatsui T, Yabashi M, Nureki O, Matsumura H, Inoue T, Iwata S, Mizohata E,
J Biochem.,
(2016).
"Structural Insights into Divalent Cation Modulations of ATP-Gated P2X Receptor Channels"
Kasuya G, Fujiwara Y, Takemoto M, Dohmae N, Nakada-Nakura Y, Ishitani R, Hattori M, Nureki O,
Cell Rep.,
14
932-944
(2016).
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